The sensible man,' Crow had said (to Sherlock Holmes), 'don't look to confirm what he already knows -- he looks to deny it. Finding evidence that backs up your theories ain't useful, but finding evidence that your theories are wrong is priceless. Never try to prove yourself right -- always try to prove yourself wrong instead.

Tedious as it may appear to some to dwell on the discovery of odds and ends that have, no doubt, been thrown away by the owner as rubbish ... yet it is by the study of such trivial details that Archaeology is mainly dependent for determining the date of earthworks. ... Next to coins fragments of pottery afford the most reliable of all evidence ...

I like the scientific spirit—the holding off, the being sure but not too sure, the willingness to surrender ideas when the evidence is against them: this is ultimately fine—it always keeps the way beyond open—always gives life, thought, affection, the whole man, a chance to try over again after a mistake—after a wrong guess.

Every time we let ourselves believe for unworthy reasons, we weaken our powers of self-control, of doubting, of judicially and fairly weighing evidence. We all suffer severely enough from the maintenance and support of false beliefs and the fatally wrong actions which they lead to, and the evil born when one such belief is entertained is great and wide.

In a world where critical thinking skills are almost wholly absent, repetition effectively leapfrogs the cognitive portion of the brain. It helps something get processed as truth. We used to call it unsubstantiated buy-in. Belief without evidence. It only works in a society where thinking for one's self is discouraged. That's how we lost our country.

When even the brightest mind in our world has been trained up from childhood in a superstition of any kind, it will never be possible for that mind, in its maturity, to examine sincerely, dispassionately, and conscientiously any evidence or any circumstance which shall seem to cast a doubt upon the validity of that superstition. I doubt if I could do it myself.

Well, did he do it?"She always asked the irrelevant question. It didn't matter in terms of the strategy of the case whether the defendant "did it" or not. What mattered was the evidence against him -- the proof -- and if and how it could be neutralized. My job was to bury the proof, to color the proof a shade of gray. Gray was the color of reasonable doubt.

But at the same time, there must never be the least hesitation in giving up a position the moment it is shown to be untenable. It is not going too far to say that the greatness of a scientific investigator does not rest on the fact of his having never made a mistake, but rather on his readiness to admit that he has done so, whenever the contrary evidence is cogent enough.

For God to prove himself on demand, physically, would be a grave disappointment, and the strongest Christians should be considerably grateful that he chooses not to do so. The skeptic endlessly demands proof, yet God refuses to insult the true intelligence of man, the '6th sense', the chief quality, the acumen which distinguishes man from the rest of creation, faith.

We are betrayed by our maps of salience. They plot our narratives, identify our enemies and then coat them in distorting layer of loathing and dread. We feel that hunch - withdraw - and then conduct a post factum search for evidence that justifies it. We are motivated to fight our foes because we are emotional about them, but emotion is the territorial scent-mark of irrationality.

What baseball managers did do, on occasion, beginning in the early 1980s, was hire some guy who knew how to switch on the computer. But they did this less with honest curiosity than in the spirit of a beleaguered visitor to Morocco hiring a tour guide: pay off one so that the seventy-five others will stop trying to trade you their camels for your wife. Which one you pay off is largely irrelevant.

Quite recently the human descent theory has been stigmatized as the 'gorilla theory of human ancestry.' All this despite the fact that Darwin himself, in the days when not a single bit of evidence regarding the fossil ancestors of man was recognized, distinctly stated that none of the known anthropoid apes, much less any of the known monkeys, should be considered in any way as ancestral to the human stock.

We're surrounded by people who don’t make that distinction. If you say to them ‘there’s a monster living in my closet, you can’t see him, but you gotta have faith that he’s there’ people would say ‘well that’s ridiculous, you’re out of you’re mind, you should be locked up’ but the same thing does not apply to a guy living on a cloud... We suspend our powers of logic.

The most preposterous notion that Homo sapiens has ever dreamed up is that the Lord God of Creation, Shaper and Ruler of all the Universes, wants the saccharine adoration of His creatures, can be swayed by their prayers, and becomes petulant if He does not receive this flattery. Yet this absurd fantasy, without a shred of evidence to bolster it, pays all the expenses of the oldest, largest, and least productive industry in all history.

I believe in you and me. I'm like Albert Schweitzer and Bertrand Russell and Albert Einstein in that I have a respect for life -- in any form. I believe in nature, in the birds, the sea, the sky, in everything I can see or that there is real evidence for. If these things are what you mean by God, then I believe in God. But I don't believe in a personal God to whom I look for comfort or for a natural on the next roll of the dice.