I had no doubt that Tiny thought he got depressed, but that was probably because he had nothing to compare it to. Still, what could I say? that I didn't just feel depressed - instead, it was like the depression was the core of me, of every part of me, from my mind to my bones? That if he got blue, I got black? That I hated those pills so much because I knew how much I relied on them to live? No, I couldn't say any of this because when it all comes down to it, nobody wants to hear it. No matter how much they like you or love you, they don't want to hear it.

You wake up one morning and all your spiritual feelings are gone. You pray, but nothing happens. You rebuke the devil, but it doesn't change anything. You go through spiritual exercises...you have your friends pray for you...you confess every sin you can imagine, then go around asking forgiveness of everyone you know. You fats...still nothing. You begin to wonder how long this spiritual gloom might last. Days? Weeks? Months? Will it ever end? ....it feels as if your prayers simply bounce off the ceiling. In utter depression, you cry out, "What's the matter with me?

Depression is a painfully slow, crashing death. Mania is the other extreme, a wild roller coaster run off its tracks, an eight ball of coke cut with speed. It's fun and it's frightening as hell. Some patients - bipolar type I - experience both extremes; other - bipolar type II - suffer depression almost exclusively. But the "mixed state," the mercurial churning of both high and low, is the most dangerous, the most deadly. Suicide too often results from the impulsive nature and physical speed of psychotic mania coupled with depression's paranoid self-loathing.

People get sick and sometimes they get better and sometimes they don't. And it doesn't matter if the sickness is cancer or if it's depression. Sometimes the drugs work and sometimes they don't. Sometimes the drugs work for a while and then they stop. Sometimes the alternative stuff works and sometimes it doesn't. And sometimes you wonder if no outside interference makes any difference at all; if an illness is like a storm, if it simply has to run its course and, at the end of it, depending on how robust you are, you will be alive. Or you will be dead.

The night was blustery and raw, with a chill wet wind blowing down the avenues, and when Rose and I met Françoise and her son and a friend at La Lorraine, a glittering brassiere not far from L'Étoile, rain was descending from the heavens in torrents. Someone in the group, sensing my state of mind, apologized for the evil night, but I recall thinking that even if this were one of those warmly scented and passionate evenings for which Paris is celebrated I would respond like the zombie I had become. The weather of depression is unmodulated, its light a brownout.

Depression is about anger, it is about anxiety, it is about character and heredity. But it is also about something that is in its way quite unique. It is the illness of identity, it is the illness of those who do not know where they fit, who lose faith in the myths they have so painstakenly created for themselves. [...] It is a plague - especially if you add in its various forms of expression, like alcoholism, anorexia, bulimia, drug addiction, compulsive behaviour of one kind or another. They're all the same things: attempts to avoid disappearance, or nothingness, or chaos.

Midland City had a goddess of discord all its own. This was a goddess who could not dance, would not dance, and hated everybody at the high school. She would like to claw away her face, she told us, so that people would stop seeing things in it that had nothing to do with what she was like inside. She was ready to die at any time, she said, because what men and boys thought about her and tried to do to her made her so ashamed. One of the first things she was going to do when she got to heaven, she said, was to ask somebody what was written on her face and why had it been put there.

Two and a half years ago I’d learned to stop wanting comfort from the people around me, because they couldn’t give it. We were all too scared. I was terrified and so were they. No one could understand what was happening to me, and when they couldn’t make me better they felt helpless and guilty and eventually resentful. Yes, they loved me, my head knew that even if my heart couldn’t feel it, but there was a small part of them that was angry. As if it was my choice to become depressed and that I was deliberately resisting the medication that was meant to fix me.

All these years, her sole objective had been to keep still and hope no one would ever know. She had been a mistress of stillness. She had mastered the simulation of peace without a wisp of real peace, like a nun from a silent order who was screaming inside her head, or a yogi racked with pain. How she had managed to fool anyone, let alone everyone, mystified her (how obtuse people were!) and, oddly, made her extraordinarily bitter. Because the price of her gift for evasion was to have no one, not one person, who understood how horrible she felt. All the time. Absolutely all the time.

For action, whatever its immediate purpose, also implies relief at doing something, anything, and the joy of exertion. This is the optimism that is inherent in, and proper and indispensable to action, for without it nothing would ever be undertaken. It in no way suppresses the critical sense or clouds the judgment. On the contrary this optimism sharpens the wits, it creates a certain perspective and, at the last moment, lets in a ray of perpendicular light which illuminates all one's previous calculations, cuts and shuffles them and deals you the card of success, the winning number.

The English language lacks the words to mourn an absence. For the loss of a parent, grandparent, spouse, child or friend, we have all manner of words and phrases, some helpful some not. Still we are conditioned to say something, even if it is only “I’m sorry for your loss.” But for an absence, for someone who was never there at all, we are wordless to capture that particular emptiness. For those who deeply want children and are denied them, those missing babies hover like silent ephemeral shadows over their lives. Who can describe the feel of a tiny hand that is never held?

Everything feels like a badly designed computer game in which you fall into a pit that doesn't kill you but from which there's absolutely no escape. For a while you kick against the walls, but the walls get higher no matter how hard and fast you press all the buttons you can find. And sooner or later you'll realize there's one you haven't tried yet. The power switch.[...] So she began reaching for the button herself, but she never tried quite hard enough, because some part of her was still alive. She didn't want to throw the machine away. She just wanted to start again.

Anna Petrovna: Kolya, my dearest, stay at home.Ivanov: My love, my unhappy darling, I beg you, don't stop me going out in the evenings. It's cruel and unjust on my part, but let me commit that injustice. It's an agony for me at home. As soon as the sun disappears, my spirit begins to be weighed down by depression. What depression! Don't ask why. I myself don't know. I swear by God's truth I don't know. Here I'm in anguish, I go to the Lebedevs and there it's still worse; I return from there and here it's depression again, and so all night... Simply despair!

This story ["The Depressed Person"] was the most painful thing I ever wrote. It's about narcissism, which is a part of depression. The character has traits of myself. I really lost friends while writing on that story, I became ugly and unhappy and just yelled at people. The cruel thing with depression is that it's such a self-centered illness - Dostoevsky shows that pretty good in his "Notes from Underground". The depression is painful, you're sapped/consumed by yourself; the worse the depression, the more you just think about yourself and the stranger and repellent you appear to others.

In our family "whim-wham" is code, a defanged reference to any number of moods and psychological disorders, be they depressive, manic, or schizoaffective. Back in the 1970s and '80s - when they were all straight depression - we called them "dark nights of the soul." St. John of the Cross's phrase ennobled our sickness, spiritualized it. We cut God out of it after the manic breaks started in 1986, the year my dad, brother, and I were all committed. Call it manic depression or by its new, polite name, bipolr disorder. Whichever you wish. We stick to our folklore and call it the whim-whams.