The decision-making part of the brain of an individual who has been using crystal meth is very interesting. When Carly and Andy were in their apartment, they ran out of drugs. They sold every single thing they had except two things: a couch and a blow torch. They had to make a decision because something had to be sold to buy more drugs. A normal person would automatically think, Sell the blow torch. But Andy and Carly sat on the couch, looking at the couch and looking at the blow torch, and the choice brought intense confusion. The couch? The blow torch? I mean, we may not need the blow torch today, but what about tomorrow? If we sell the couch, we can still sit wherever we want. But the blow torch? A blow torch is a very specific item. If you’re doing a project and you need a blow torch, you can’t substitute something else for it. You would have to have a blow torch, right? In the end, they sold the couch.

However, on one occasion, several years ago, I was idiot enough to take a dose of LSD. (I did it to please a woman.) I had what is known as a 'bad trip'. It was a very bad trip. I shall not attempt to describe what I experienced on that dreadful and rather shameful occasion. (I will only add: it concerned entrails.) In fact it would be extremely hard, even impossible, to put it properly into words. It was something morally, spiritually horrible, as if one's stinking inside had emerged and become the universe: a surging emanation of dark half-formed spiritual evil, something never ever to be escaped from. 'Undetachable,' I remember, was a word which somehow 'came along' with the impression of it. In fact the visual images involved were dreadfully clear and, as it were, authoritative ones and they are rising up in front of me at this moment, and I will not write about them. Of course i never took LSD again.

Slowly, even though I thought it would never happen, New York lost its charm for me. I remember arriving in the city for the first time, passing with my parents through the First World's Club bouncers at Immigration, getting into a massive cab that didn't have a moment to waste, and falling in love as soon as we shot onto the bridge and I saw Manhattan rise up through the looks of parental terror reflected in the window. I lost my virginity in New York, twice (the second one wanted to believe he was the first so badly). I had my mind blown open by the combination of a liberal arts education and a drug-popping international crowd. I became tough. I had fun. I learned so much.But now New York was starting to feel empty, a great party that had gone on too long and was showing no sign of ending soon. I had a headache, and I was tired. I'd danced enough. I wanted a quiet conversation with someone who knew what load-shedding was.

To stop the drug traffic is not the best way to prevent people from using drugs. The best way is to practice the Fifth Precept and to help others practice. Consuming mindfully is the intelligent way to stop ingesting toxins into our consciousness and prevent the malaise from becoming overwhelming. Learning the art of touching and ingesting refreshing, nourishing, and healing elements is the way to restore our balance and transform the pain and loneliness that are already in us. To do this, we have to practice together. The practice of mindful consuming should become a national policy. It should be considered true peace education... Those who are destroying themselves, their families, and their society by intoxicating themselves are not doing it intentionally. Their pain and loneliness are overwhelming, and they want to escape. They need to be helped, not punished. Only understanding and compassion on a collective level can liberate us (78-79).

How about this? Hong Kong had been appropriated by British drug pushers in the 1840s. We wanted Chinese silk, porcelain, and spices. The Chinese didn't want our clothes, tools, or salted herring, and who can blame them? They had no demand. Our solution was to make a demand, by getting large sections of the populace addicted to opium, a drug which the Chinese government had outlawed. When the Chinese understandably objected to this arrangement, we kicked the fuck out of them, set up a puppet government in Peking that hung signs on parks saying NO DOGS OR CHINESE, and occupied this corner of their country as an import base. Fucking godawful behavior, when you think about it. And we accuse them of xenophobia. It would be like the Colombians invading Washington in the early twenty-first century and forcing the White House to legalize heroin. And saying, "Don't worry, we'll show ourselves out, and take Florida while we're at it, okay? Thanks very much.

No more junk talk, no more lies. No more mornings in the hospital getting bad blood drained out of me. No more doctors trying to analyse what makes me a drug addict. No more futile attempts at trying to control my heroin use. No more defending myself when I know I am practically indefensible. No more police using me as practice. No more ODs, no more losses. No more trying to take an intellectual position on my heroin addiction when it takes more than it gives. No more dope-sick mornings, no more slow suicide, no more pain without end.No more AA. No more NA. No more mind control. No more being a victim, no more looking for reasons in childhood, in God in anything but what exists in HERE. No more admitting I am powerless. Down the dusty Los Angeles sidewalks, down the urine stained London back alleys … there goes the connection fading into the crowd like a 1960’s Polaroid.“Business…?”“Whachoo need…?”“Chiva…?

Evans turned away, did something with his left eyelid for the benefit of the other two. "It's got him," he smirked. "He's tuned-in from now on."Time started to slow up and act crazy. Minutes took much longer to pass than they had before. It was hard for him to adjust himself to the new ratio, he got all balled-up. When it seemed like half an hour had gone by, the radio would still be playing only the first chorus of the same selection that had begun a good thirty minutes before. Otherwise, nothing much happened. Vinnie was doing a good deal of muffled giggling over there on the divan. The stranger who had been sitting reading the paper got up, yawned, stretched ponderously, and strolled out into the hall, with a muttered "Happy landing!" by way of leave-taking. He didn't come back again any more.Turner looked down one time and a quarter of an inch of charred paper was all that was left between his fingers. Then the next time he looked there was a full length cigarette again.

A lady that I know just came from Colombia. She laughed because I did not understand. She held out some marijuana uh-huh, said it was the finest in the land. I said, no-no-no-no, i dont smoke it no more. It only makes me fall on the floor.No thank you please, it only makes me sneeze, and then it makes it hard to find the door. A lady that i know just came from Morrocco, Spain. She laughed because i did not understand. She held out a ten-pound bag of cocaine, said it was the finest in the land. I said no-no-no-no, i don't *sniff* no more, it only makes me fall on the floor. No thank you please, it only makes me sneeze, and then it makes it hard to find the door.A lady that i know just came from Tennesee. She laughed because i did not understand. She held out a jug of moonshine, uh-huh, said it was the finest in the land. I said no-no-no-no, i don't drink it no more, it only makes me fall on the floor. No thank you please, it only makes me sneeze, and then it makes it hard to find the door.Ringo Starr's No-No Song

I look in the jewelry box where Joanie found the drugs. She showed me a miniature Ziploc bag filled with a clear, hard rock.“What is this?” I said. I never did drugs, so I had no idea. Heroin? Cocaine? Crack? Ice? “What is this?” I screamed at Alex, who screamed back, “It’s not like I shoot it!”A plastic ballerina pops up and slowly twirls to a tinkling song whose sound is discordant and deformed. The pink satin liner is dirty, and other than a black pearl necklace, the box holds only rusty paper clips and rubber bands noosed with Alex’s dark hair. I see a note stuck to the mirror and pick up the jewelry box and move the ballerina aside. She twirls against my finger. The note says, I wouldn’t hide them in the same place twice.I let out a short breath through my nose. Good one, Alex. I close the jewelry box and shake my head, missing her tremendously. I wish she never went back to boarding school, and I don’t understand her sudden change of plans. What did they fight about? What could have been so bad?

Somewhere in the distance I hear the bucket clatter to the floor. I plunge the knife into his head, again and again. His arms lash out blindly, getting in the way. Blood mixes with water cascading to the floor. Meathead staggers to his feet, pulling off his shirt, trying to peel away the agony, but his skin comes away with it, leaving a raw, red mess.There’s a shrill alarm and the sound of pounding feet. I hurl the knife through the bars at the window. A blur of dark faces converge in my vision, fists and feet, punching and kicking. Meathead’s mates are yanking me off, trying to hurt me. Screws come rushing and soon they’re everywhere as I’m half-carried, half-dragged along the corridor.‘Blimey,’ a thought comes from somewhere in all the chaos, ‘I’ve only been out a day and already I’m heading straight back down the chokey!’ The last thing I see, as a screaming Meathead is hurried to the hospital, is my cellmate in the middle of the crowd peering worriedly after me. Course he’s worried! The stinky bastard is wondering where his next bit of scag is coming from!

I didn't realize there was a ranking." I said. "Sadie frowned. "What do you mean?" "A ranking," I said. "You know, what's crazier than what." "Oh, sure there is," Sadie said. She sat back in her chair. "First you have your generic depressives. They're a dime a dozen and usually pretty boring. Then you've got the bulimics and the anorexics. They're slightly more interesting, although usually they're just girls with nothing better to do. Then you start getting into the good stuff: the arsonists, the schizophrenics, the manic-depressives. You can never quite tell what those will do. And then you've got the junkies. They're completely tragic, because chances are they're just going to go right back on the stuff when they're out of here." "So junkies are at the top of the crazy chain," I said. Sadie shook her head. "Uh-uh," she said. "Suicides are." I looked at her. "Why?" "Anyone can be crazy," she answered. "That's usually just because there's something screwed up in your wiring, you know? But suicide is a whole different thing. I mean, how much do you have to hate yourself to want to just wipe yourself out?

I would rather go mad, gone down the dark road to Mexico, heroin dripping in my veins, eyes and ears full of marijuana, eating the god Peyote on the floor of a mudhut on the border or laying in a hotel room over the body of some suffering man or woman; rather jar my body down the road, crying by a diner in the Western sun; rather crawl on my naked belly over the tincans of Cincinnati; rather drag a rotten railroad tie to a Golgotha in the Rockies; rather, crowned with thorns in Galveston, nailed hand and foot in Los Angeles, raised up to die in Denver, pierced in the side in Chicago, perished and tombed in New Orleans and resurrected in 1958 somewhere on Garret Mountain, come down roaring in a blaze of hot cars and garbage, streetcorner Evangel in front of City I-Tall, surrounded by statues of agonized lions, with a mouthful of shit, and the hair rising on my scalp, screaming and dancing in praise of Eternity annihilating the sidewalk, annihilating reality, screaming and dancing against the orchestra in the destructible ballroom of the world, blood streaming from my belly and shoulders flooding the city with its hideous ecstasy, rolling over the pavements and highways by the bayoux and forests and derricks leaving my flesh and my bones hanging on the trees.

As a consequence of natural analgesic actions or as a result of the administration of drugs that interfere with body signaling (painkillers, anesthetics), the brain receives a distorted view of what the body state really is at the moment. We know that in situations of fear in which the brain chooses the running option rather than freezing, the brain stem disengages the part of the pain-transmission circuitry, a bit like pulling the plug. The periqueductal gray, which controls these responses, can also command the secretion of natural opioids and achieve precisely what taking an analgesic would achieve -- elimination of pain signals.In the strict sense, we are dealing here with a hallucination of the body because what the brain registers in its maps and the conscious mind feels do not correspond to the reality that might be perceived. Whenever we ingest molecules the have the power to modify the transmission or mapping of body signals, we play on this mechanism. Alcohol does it; so do analgesics and anesthetics, as well as countless drugs of abuse. It is patently clear that, other than out of curiousity, humans are drawn to such molecules because of their desire to generate feelings of well-being, feelings in which pain signals are obliterated and pleasure signals induced.

In the City Market is the Meet Café. Followers of obsolete, unthinkable trades doodling in Etruscan, addicts of drugs not yet synthesized, pushers of souped-up harmine, junk reduced to pure habit offering precarious vegetable serenity, liquids to induce Latah, Tithonian longevity serums, black marketeers of World War III, excusers of telepathic sensitivity, osteopaths of the spirit, investigators of infractions denounced by bland paranoid chess players, servers of fragmentary warrants taken down in hebephrenic shorthand charging unspeakable mutilations of the spirit, bureaucrats of spectral departments, officials of unconstituted police states, a Lesbian dwarf who has perfected operation Bang-utot, the lung erection that strangles a sleeping enemy, sellers of orgone tanks and relaxing machines, brokers of exquisite dreams and memories tested on the sensitized cells of junk sickness and bartered for raw materials of the will, doctors skilled in the treatment of diseases dormant in the black dust of ruined cities, gathering virulence in the white blood of eyeless worms feeling slowly to the surface and the human host, maladies of the ocean floor and the stratosphere, maladies of the laboratory and atomic war... A place where the unknown past and the emergent future meet in a vibrating soundless hum... Larval entities waiting for a Live One...

To list all the great discoveries in the field of science and medicine during the past century, such as aspirin, insulin, penicillin, and the streptomycin drugs would require the undivided attention of a medical historian and a veritable encyclopedia to record them.And yet, there are still many diseases that plague man of which he has no knowledge. They eat and ravage his mind and body with excruciating pain and torture, and he is utterly helpless against them. He not only does not know their origin, but has not the slightest inkling of their nature or how to fortify himself against their attacks. He must sit, like a condemned criminal, in agonizing torture, waiting for blessed death.If man, and the other forms of life upon this earth, are a mere by-product of an 'over-all plan' of a 'supreme intelligence,' then I denounce such a scheme as tyrannical and barbaric. Why should we be made to suffer such excruciating pains and penalties of life to satisfy that from which we derive no benefit, and where death negates all of our efforts; and which makes the purpose of life, our hopes and desires, our ambitions and aspirations, a cruel mockery?O prayer, thy name is failure!O God, thou art a cruel myth!You will not find a single mention of these great humanitarian achievements in the so-called 'Book of Books'; not a single reference about the nature and cure of disease; not a word regarding those inventions that have so mercifully lifted the burden of toil from the backs of labor.