For six days I didn’t get up except to make a cup of tea, or fry an egg, or lie in the skinny bath gazing at a cracked ceiling. The days punished me with their slowness, piling up the hours on me, spreading their joylessness about the room.A doctor would have said I was suffering from depression. Everything I have read since suggests this was the case. But when you are in the grip of something like that it doesn’t usefully announce itself. No. what happens is you sit in a dark, dark cave, and you wait. If you are lucky there is a pinprick of light, and if you are especially lucky that pinprick will grow larger and larger, until one day the cave appears to slip behind, and just like that you find yourself in daylight and free. This is how it happened for me.

People with family histories of alcoholism tend to have lower levels of endorphins- the endogenous morphine that is responsible for many of our pleasure responses- than do people genetically disinclined to alcoholism. Alcohol will slightly raise the endorphin level of people without the genetic basis for alcoholism; it will dramatically raise the endorphin level of people with that genetic basis. Specialists spend a lot of time formulating exotic hypotheses to account for substance abuse. Most experts point out, strong motivations for avoiding drugs; but there are also strong motivations for taking them. People who claim not to understand why anyone would get addicted to drugs are usually people who haven't tried them or who are genetically fairly invulnerable to them.

The light in that room was a glow; I seem to remember the color green, or perhaps flowers. A pale green sheet covered his inert body but not his head, which lay (eyes closed, mouth set in a tense and terrible grimace) unmoving. Gianluca. Barely able to see, barely able to stand - my knees kept buckling – and breathing so quietly I thought that I, too, might die; that out of shock, I would just drift away, the shell of my body cracking open. No longer anchored by my brother’s love, I would be reabsorbed by sky. Gianluca. If there was never another sound in the world, I would understand – yes, that would be appropriate, it would be fitting. This was the antithesis of music, the antithesis of noise. My brother’s death seemed to demand silence of all the world. Gianluca.

It's an unfortunate word, 'depression', because the illness has nothing to do with feeling sad, sadness is on the human palette. Depression is a whole other beast. It's when your old personality has left town and been replaced by a block of cement with black tar oozing through your veins and mind. This is when you can't decide whether to get a manicure or jump off a cliff. It's all the same. When I was institutionalised I sat on a chair unable to move for three months, frozen in fear. To take a shower was inconceivable. What made it tolerable was while I was inside, I found my tribe - my people. They understood and unlike those who don't suffer, never get bored of you asking if it will ever go away? They can talk medication all hours, day and night; heaven to my ears.

In its severe forms, depression paralyzes all of the otherwise vital forces that make us human, leaving instead a bleak, despairing, desperate, and deadened state. . .Life is bloodless, pulseless, and yet present enough to allow a suffocating horror and pain. All bearings are lost; all things are dark and drained of feeling. The slippage into futility is first gradual, then utter. Thought, which is as pervasively affected by depression as mood, is morbid, confused, and stuporous. It is also vacillating, ruminative, indecisive, and self-castigating. The body is bone-weary; there is no will; nothing is that is not an effort, and nothing at all seems worth it. Sleep is fragmented, elusive, or all-consuming. Like an unstable, gas, an irritable exhaustion seeps into every crevice of thought and action.

Like an attack this melancholy comes from time to time. I don't know at what intervals, and slowly covers my sky with clouds. It begins with an unrest in the heart, with a premonition of anxiety, probably with my dreams at night. People, houses, colors, sounds that otherwise please me become dubious and seem false. Music gives me a headache. All my mail becomes upsetting and contains hidden arrows. At such times, having to converse with people is torture and immediately leads to scenes... Anger, suffering, and complaints are directed at everything, at people, at animals, at the weather, at God, at the paper in the book one is reading, at the material of the very clothing one has on. But anger, impatience, complaints and hatred have no effect on things and are deflected from everything, back to myself.

عادة ما أشعر انى خفيفة قادرة على ان أطير وأنا مستقرة فى مقعد أقرأ رواية ممتعة. حين أشعر بنفسى ثقيلة أعرف أنى على مشارف نوبة جديدة من الاكتئاب

It's one of these juvenile therapy scams,” he went on, sprinkling a pinch of the Golden Virginia tobacco along the rolling paper. “They advertise help for your troubled teen by staring at the stars and singing ‘Kumbaya’. Instead, it’s a bunch of bearded nutjobs left in charge of some of the craziest kids I’ve ever seen in my life—bulimics, nymphos, cutters trying to saw their wrists with the plastic spoons from lunch. You wouldn’t believe the shit that went on.” He shook his head. “Most of the kids had been so mentally screwed by their parents they needed more than twelve weeks of wilderness. They needed reincarnation. To die and just come back as a grasshopper, as a fucking weed. That’d be preferable to the agony they were in just by being alive.

Minds me of a story they tell about Willy Feeley when he was a young fella. Willy was bashful, awful bashful. Well, one day he takes a heifer over to Graves' bull. Ever'body was out but Elsie Graves, and Elsie wasn't bashful at all. Willy, he stood there turnin' red an' he couldn't even talk. Elsie says, 'I know what you come for; the bull's out in back a the barn.' Well, they took the heifer out there an' Willy an' Elsie sat on the fence to watch. Purty soon Willy got feelin' purty fly. Elsie looks over an' says, like she don't know, 'What's a matter, Willy?' Willy's so randy, he can't hardly set still. 'By God,' he says, 'by God, I wisht I was a-doin' that!' Elsie says, 'Why not, WIlly? It's your heifer.

That there is in this world neither brains, nor goodness, nor good sense, but only brute force. Bloodshed. Starvation. Death. That there was not the slightest hope not even a glimmer of hope, of justice being done. It would never happen. No one would ever do it. The world was just one big Babi Yar. And there two great forces had come up against each other and were striking against each other like hammer and anvil, and the wretched people were in between, with no way out; each individual wanted only to live and not be maltreated, to have something to eat, and yet they howled and screamed and in their fear they were grabbing at each other’s throats, while I, little blob of watery jelly, was sitting in the midst of this dark world. Why? What for? Who had done it all? There was nothing, after all, to hope for! Winter. Night.

People often say “Just look for the silver lining.” But what do you say to the person surrounded by fog? They don’t see a fluffy object in the sky, blocking the sun for a moment or two. But instead, they see everything as it was before, but through the murky, un-clarity of hopelessness. As if they were standing at the bottom of a grimy lake except able to breathe. But not wanting to because with each breath they grow numb from the cold loneliness. What if they’re surrounded by a dreary blanket of darkness, made up of their own thoughts, too impenetrable for any light to break through? So what do you tell that person who, as far as the eye could see, only sees fog? A place where there is no silver lining peeking around the corner. Imagine a place where your only companion is the confusion you walk around with.

The industrial and technological revolutions have made our lives simpler, in terms of what is physically required of us on a daily basis, but they have also made it possible for us to do a whole lot less than we ought to be doing, and we suffer for it.We have become flabby and overweight; our joints and muscles have become stiff from lack of use. We suffer from all sorts of problems related to our lack of physical exercise; it affects us on all levels, causing high blood pressure, increased cholesterol, anxiety, depression, insomnia and the list goes on and on.We know, too, how much better we feel for a bit of exercise. Those “feel-good” hormones lift our spirits, boost self-esteem and improve our overall sense of well-being. It’s a sort of built-in reward system. There’s a reason for that. It’s because we are meant to be active.

The results of decades of neurotransmitter-depletion studies point to one inescapable conclusion: low levels or serotonin, norepinephrine or dopamine do not cause depression. here is how the authors of the most complete meta-analysis of serotonin-depletion studies summarized the data: "Although previously the monoamine systems were considered to be responsible for the development of major depressive disorder (MDD), the available evidence to date does not support a direct causal relationship with MDD. There is no simple direct correlation of serotonin or norepinephrine levels in the brain and mood.' In other words, after a half-century of research, the chemical-imbalance hypothesis as promulgated by the drug companies that manufacture SSRIs and other antidepressants is not only with clear and consistent support, but has been disproved by experimental evidence.

It is not depression or anxiety that truly hurts us. It is our active resistance against these states of mind and body. If you wake up with low energy, hopeless thoughts, and a lack of motivation - that is a signal from you to you. That is a sure sign that something in your mind or in your life is making you sick, and you must attend to that signal. But what do most people do? They hate their depressed feelings. They think "Why me?" They push them down. They take a pill. And so, the feelings return again and again, knocking at your door with a message while you turn up all the noise in your cave, refusing to hear the knocks. Madness. Open the door. Invite in depression. Invite anxiety. Invite self-hatred. Invite shame. Hear their message. Give them a hug. Accept their tirades as exaggerated mistruths typical of any upset person. Love your darkness and you shall know your light.

John says I musn't lose my strength, and has me take cod liver oil and lots of tonics and things, to say nothing of ale and wine and rare meat.Dear John! He loves me very dearly, and hates to have me sick. I tried to have a real earnest reasonable talk with him the other day, and tell him how I wish he would let me go and make a visit to Cousin Henry and Julia.But he said I wasn't able to go, nor able to stand it after I got there; and I did not make out a very good case for myself, for I was crying before I had finished.It is getting to be a great effort for me to think straight. Just this nervous weakness I suppose.And dear John gathered me up in his arms, and just carried me upstairs and laid me on the bed, and sat by me and read to me till it tired my head.He said I was his darling and his comfort and all he had, and that I must take care of myself for his sake, and keep well.